Levels of p53 protein as biomarker in plasma of workers exposed to carcinogenic polycyclic aromatic hydrocarbons
نویسندگان
چکیده
Levels of p53 protein as biomarker in plasma of workers exposed to carcinogenic polycyclic aromatic hydrocarbons Mehdi Zare a b c , Seyed Jamaleddin Shahtaheri a , Parvin Mehdipur d , Mohammad Shekari c e & Shahram Zare e a Department of Occupational Health Engineering, School of Public Health, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran b Department of Occupational Health Engineering, School of Public Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran c Research Centre for Molecular Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran d Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran e Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran Accepted author version posted online: 10 Dec 2012.Published online: 17 Dec 2012.
منابع مشابه
Risk Assessment of Polycyclic Aromatic Hydrocarbons in Pasta Products Consumed in Nigeria
Background: The present study aimed to quantitatively determine polycyclic aromatic hydrocarbons in pastas consumed in Nigeria with the view of estimating the daily intake amount and the possible risks to consumers. Methods: Sixteen polycyclic aromatic hydrocarbons (PAHs) were determined in locally produced and imported pasta using a GC-Mass Spectrometer. Estimation of daily intake was done on...
متن کاملSolid Phase Extraction for 1-Hydroxypyrene as a Biomarker of Occupational Exposure to PAHs Prior to High Performance Liquid Chromatography
Urinary 1-hydroxypyrene is frequently used as a major metabolite and biological indicator of the overall exposure to polycyclic aromatic hydrocarbons. In this study, solid phase extraction was appropriately conditioned with regard to sample pH, sample concentration, loading flow rate, elution solvent, washing solvent, sample volume and sorbent mass. Octadecyl silica cartridge (C<su...
متن کاملOGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage
Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...
متن کاملSimultaneous Determination of 13 Priority Polycyclic Aromatic Hydrocarbons in Tehran’s Tap Water and Water for Injection Samples Using Dispersive Liquid-Liquid Micro Extraction Method and Gas Chromatography-Mass Spectrometry
Abstract Polycyclic aromatic hydrocarbons (PAHs) are classified as persistent and carcinogenic organic pollutants. PAHs contamination has been reported in water. Many of relevant regulatory bodies such as EU and EPA have regulated the limit levels for PAHs in drinking water. In this study, 13 priority polycyclic aromatic hydrocarbons (PAHs) were determined in tap water samples of Tehran and wat...
متن کاملIdentification of an albumin-like protein in plasma of Atlantic cod (Gadus morhua) and its biomarker potential for PAH contamination
Increased research efforts are currently focusing on Atlantic cod (Gadus morhua) and its significance for monitoring the contaminant situation in marine environments. Polycyclic aromatic hydrocarbons (PAHs) are well known toxic and carcinogenic compounds, thus continuous monitoring is required to ensure ecosystem sustainability and human food safety. A sensitive biomarker of PAH exposure in hum...
متن کامل